Nerolidyl acetate (isomer unspecified) (CAS 2306-78-7) — Woody Middle Note Fragrance Ingredient
Nerolidyl acetate (isomer unspecified)
CAS 2306-78-7
What Is Nerolidyl acetate (isomer unspecified)?
Nerolidyl acetate is a synthetic fragrance ingredient often used to add woody, floral nuances to perfumes. You’ll encounter it in body care products and fine fragrances. This versatile ingredient helps create depth and longevity in scent compositions, making it valuable for perfumers aiming for sophisticated accords.
Safety Profile
GENERALLY SAFEWhat Does Nerolidyl acetate (isomer unspecified) Smell Like?
Nerolidyl acetate offers a delicate balance of woody and floral notes, reminiscent of fresh lily petals with a subtle green undertone. Its dry-down reveals a gentle, slightly sweet muskiness that blends seamlessly into skin. The evolution is smooth, transitioning from a crisp top to a warm, comforting base.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used to enhance the floral bouquet, adding a subtle woody depth that balances the aldehydes.
Contributes to the smooth floral heart, providing a velvety texture to the scent.
2D Molecular Structure
SMILES: CC(C)=CCCC(C)=CCCC(C)(OC(C)=O)C=C
Chemistry, Properties & Perfumer Guide
The Chemistry
Nerolidyl acetate is a sesquiterpene ester, synthesized through esterification of nerolidol with acetic acid. Its structure allows for versatile interactions with other fragrance molecules, making it a valuable tool in perfumery. The synthetic route ensures consistency in quality and performance across batches.
Physical & Chemical Properties
| Boiling Point | N/A |
|---|---|
| Density | N/A |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-5% | Up to 10% | Adds woody-floral depth |
| Body Care | 0.5-3% | Up to 5% | Subtle floral enhancement |
Classic Accords
Tip: Use to bridge floral and woody notes for a seamless transition.
Alternatives & Comparisons
The alcohol precursor, offering similar woody notes without the ester’s sweetness.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No specific IFRA restrictions apply.
RIFM Assessment
RIFM assessment confirms safe use at current levels in fragrances.
Sustainability
Synthetic production ensures consistent quality without reliance on natural resources. The process is optimized for minimal environmental impact.
Explore Nerolidyl acetate (isomer unspecified)
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References
- PubChem CID: 2306-78-7 PubChem
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorPhysicochemical Properties
DTXSID: DTXSID70862899
Physical Properties
| Molecular Weight | 264.409 g/mol🔬 EPA CompTox |
| Density | 0.908 g/cm^3📊 OPERA |
| Boiling Point | 280 °C🔬 EPA CTX |
| Melting Point | -14.955 °C📊 OPERA |
| Flash Point | 108.692 °C📊 OPERA |
| Refractive Index | 1.469 Dimensionless📊 OPERA |
| Molar Volume | 294.606 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 5.855 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 5.855 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 5.855 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 7.79 Log10 unitless📊 OPERA |
| Water Solubility | 0 mol/L📊 OPERA |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.002 mmHg📊 OPERA |
| Viscosity | 3.538 cP📊 OPERA |
| Surface Tension | 27.264 dyn/cm📊 OPERA |
| Thermal Conductivity | 136.301 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 26.3 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 2 count💻 Computed |
| Rotatable Bonds | 8 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 82.075 cm^3/mol📊 OPERA |
| Polarizability | 32.537 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
