Pyrazine Ethanethiol (CAS 35250-53-4) — Mid Note Fragrance Ingredient

ByThe Good Scents



gourmand

Pyrazine Ethanethiol

CAS 35250-53-4

Note
mid
Volatility
medium
MW
140.2
Data as of: Jun 2026

What Is Pyrazine Ethanethiol?

Pyrazine Ethanethiol (CAS 35250-53-4) is an aroma chemical used as a fragrance and flavour ingredient. Its odour is described as bakery, sweet and fruit, placing it within the gourmand family as a mid note with medium volatility. With a molecular weight of 140.2 (formula C6H8N2S), it is handled by perfumers as a building block for compositions where a bakery character is desired. The data below is compiled from public chemical and regulatory sources.

Safety Profile

HANDLE WITH CARE

Generally safeUse with awarenessProfessional use
CAS
35250-53-4
Formula
C6H8N2S
MW
140.2
InChIKey
QKVWBAMZPUHCMO-UHFFFAOYSA-N
Pyrazine Ethanethiol 2D structure

Pyrazine Ethanethiol
C6H8N2S
Layer 1 · Enthusiast

What Does Pyrazine Ethanethiol Smell Like?

The odour profile of Pyrazine Ethanethiol is reported as bakery, sweet, fruit, garlic, spices, cold, sour, burnt, acid, warm, musky, sweaty, ammonia/urinous, wood, grass, flower, chemical, edible. The dominant facet is its bakery character, with the remaining notes adding nuance and complexity. As a mid note it contributes to the heart of a fragrance. Perceived intensity and exact character depend on concentration, the carrier and the surrounding accord.

Scent Profile

Profile derived from public odour-descriptor data; relative, not absolute.

Layer 2

Chemistry & Properties

The Chemistry

Pyrazine Ethanethiol has the molecular formula C6H8N2S and a molecular weight of 140.2 g/mol. Its canonical SMILES representation is SCCC1=CN=CC=N1. Its reported log P (XLogP) of 0.9489 indicates a moderately polar molecule, which informs how it partitions in a formula. Physical constants below are drawn from PubChem and EPA CompTox public datasets.

Physical & Chemical Properties

Molecular Weight 140.2 g/mol
Boiling Point 227.0 °C
Melting Point 42.02 °C
Flash Point 93.06 °C
Density 1.15 g/cm³
Vapor Pressure 0.0569 mmHg
Water Solubility 0.1862 g/L
XLogP 0.9489

Perfumer Guide

Note Position
Mid
Volatility
Medium
Primary Odour
Bakery

Alternatives & Comparisons

Ingredients occupying a similar odour space — useful as substitutes or companions when Pyrazine Ethanethiol is unavailable or restricted.

1
5-Hexenol CAS 821-41-0

Shares bakery, sweet, fruit character — a candidate substitute or companion in the same odour space.

2
2-Acetylthiophene CAS 88-15-3

Shares bakery, sweet, fruit character — a candidate substitute or companion in the same odour space.

3
1,6-Hexanedithiol CAS 1191-43-1

Shares bakery, sweet, fruit character — a candidate substitute or companion in the same odour space.

Layer 3

Safety & Regulatory

⚠ Regulatory Disclaimer

General reference only. IFRA, REACH and EU Cosmetics Regulation standards update periodically. Consult the current IFRA Standards Library before formulating. Not legal or regulatory advice.

IFRA Status

No IFRA restriction recorded in the data set. This is not a guarantee of unrestricted status — always confirm against the current IFRA Standards Library.

GHS Classification

Signal word: Danger

H301
Formulating with Pyrazine Ethanethiol?

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References & Sources

  1. PubChem Compound Summary (NIH) — search by InChIKey
  2. EPA CompTox Chemicals Dashboard — physicochemical & fate data
  3. IFRA Standards Library (49th / 51st Amendment)
Sources: PubChem (NIH) · EPA CompTox · IFRA Standards Library · public GHS classification. Odour descriptors are original editorial summaries of public profiles, not reproduced from any single proprietary source.

Data: PubChem (NIH), EPA CompTox, IFRA. Last reviewed: Jun 2026.

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